HLA Class II Specificity Assessed by High-Density Peptide Microarray Interactions.

ABSTRACT: The ability to predict and/or identify MHC binding peptides is an essential component of T cell epitope discovery, something that ultimately should benefit the development of vaccines and immunotherapies. In particular, MHC class I prediction tools have matured to a point where accurate selection of optimal peptide epitopes is possible for virtually all MHC class I allotypes; in comparison, current MHC class II (MHC-II) predictors are less mature. Because MHC-II restricted CD4⁺ T cells control and orchestrated most immune responses, this shortcoming severely hampers the development of effective immunotherapies. The ability to generate large panels of peptides and subsequently large bodies of peptide-MHC-II interaction data are key to the solution of this problem, a solution that

SUBMITTER: Osterbye T 

PROVIDER: S-EPMC7313418 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature