Considering Genomic Scans for Selection as Coalescent Model Choice.

ABSTRACT: First inspired by the seminal work of Lewontin and Krakauer (1973. Distribution of gene frequency as a test of the theory of the selective neutrality of polymorphisms. Genetics 74(1):175-195.) and Maynard Smith and Haigh (1974. The hitch-hiking effect of a favourable gene. Genet Res. 23(1):23-35.), genomic scans for positive selection remain a widely utilized tool in modern population genomic analysis. Yet, the relative frequency and genomic impact of selective sweeps have remained a contentious point in the field for decades, largely owing to an inability to accurately identify their presence and quantify their effects-with current methodologies generally being characterized by low true-positive rates and/or high false-positive rates under many realistic demographic models. Most of these

SUBMITTER: Harris RB 

PROVIDER: S-EPMC7313662 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature