Distinct Patterns of Selective Sweep and Polygenic Adaptation in Evolve and Resequence Studies.

ABSTRACT: In molecular population genetics, adaptation is typically thought to occur via selective sweeps, where targets of selection have independent effects on the phenotype and rise to fixation, whereas in quantitative genetics, many loci contribute to the phenotype and subtle frequency changes occur at many loci during polygenic adaptation. The sweep model makes specific predictions about frequency changes of beneficial alleles and many test statistics have been developed to detect such selection signatures. Despite polygenic adaptation is probably the prevalent mode of adaptation, because of the traditional focus on the phenotype, we are lacking a solid understanding of the similarities and differences of selection signatures under the two models. Recent theoretical and empirical studies have s

SUBMITTER: Barghi N 

PROVIDER: S-EPMC7313669 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature