An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity.

ABSTRACT: Snakebite envenoming is a major neglected tropical disease that affects millions of people every year. The only effective treatment against snakebite envenoming consists of unspecified cocktails of polyclonal antibodies purified from the plasma of immunized production animals. Currently, little data exists on the molecular interactions between venom-toxin epitopes and antivenom-antibody paratopes. To address this issue, high-density peptide microarray (hdpm) technology has recently been adapted to the field of toxinology. However, analysis of such valuable datasets requires expert understanding and, thus, complicates its broad application within the field. In the present study, we developed a user-friendly, and high-throughput web application named "Snake Toxin and Antivenom Binding Profil

SUBMITTER: Krause KE 

PROVIDER: S-EPMC7313730 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature