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Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 via Close Contact and Respiratory Droplets Among Human Angiotensin-Converting Enzyme 2 Mice.

ABSTRACT: We simulated 3 transmission modes, including close-contact, respiratory droplets and aerosol routes, in the laboratory. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be highly transmitted among naive human angiotensin-converting enzyme 2 (hACE2) mice via close contact because 7 of 13 naive hACE2 mice were SARS-CoV-2 antibody seropositive 14 days after being introduced into the same cage with 3 infected-hACE2 mice. For respiratory droplets, SARS-CoV-2 antibodies from 3 of 10 naive hACE2 mice showed seropositivity 14 days after introduction into the same cage with 3 infected-hACE2 mice, separated by grids. In addition, hACE2 mice cannot be experimentally infected via aerosol inoculation until continued up to 25 minutes with high viral concentrations.

SUBMITTER: Bao L 

PROVIDER: S-EPMC7313959 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 via Close Contact and Respiratory Droplets Among Human Angiotensin-Converting Enzyme 2 Mice.

Bao Linlin L   Gao Hong H   Deng Wei W   Lv Qi Q   Yu Haisheng H   Liu Mingya M   Yu Pin P   Liu Jiangning J   Qu Yajin Y   Gong Shuran S   Lin Kaili K   Qi Feifei F   Xu Yanfeng Y   Li Fengli F   Xiao Chong C   Xue Jing J   Song Zhiqi Z   Xiang Zhiguang Z   Wang Guanpeng G   Wang Shunyi S   Liu Xing X   Zhao Wenjie W   Han Yunlin Y   Wei Qiang Q   Qin Chuan C  

The Journal of infectious diseases 20200701 4

We simulated 3 transmission modes, including close-contact, respiratory droplets and aerosol routes, in the laboratory. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be highly transmitted among naive human angiotensin-converting enzyme 2 (hACE2) mice via close contact because 7 of 13 naive hACE2 mice were SARS-CoV-2 antibody seropositive 14 days after being introduced into the same cage with 3 infected-hACE2 mice. For respiratory droplets, SARS-CoV-2 antibodies from 3 of 10 na  ...[more]

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