Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork.

ABSTRACT: Glaucoma is the second leading cause of irreversible blindness worldwide. Primary open angle glaucoma (POAG), the most common form of glaucoma, is often associated with elevation of intraocular pressure (IOP) due to the dysfunction of trabecular meshwork (TM) tissues. Currently, an ex vivo human anterior segment perfusion cultured system is widely used to study the effects of glaucoma factors and disease modifying drugs on physiological parameters like aqueous humor (AH) dynamics and IOP homeostasis. This system requires the use of freshly enucleated intact human eyes, which are sparsely available at very high cost. In this study, we explored the feasibility of using human donor corneoscleral segments for modeling morphological and biochemical changes associated with POAG. Among the number

SUBMITTER: Kasetti RB 

PROVIDER: S-EPMC7314024 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature