Environmental exposures and breast cancer risk in the context of underlying susceptibility: A systematic review of the epidemiological literature.

ABSTRACT:

Background

The evidence evaluating environmental chemical exposures (ECE) and breast cancer (BC) risk is heterogeneous which may stem in part as few studies measure ECE during key BC windows of susceptibility (WOS). Another possibility may be that most BC studies are skewed towards individuals at average risk, which may limit the ability to detect signals from ECE.

Objectives

We reviewed the literature on ECE and BC focusing on three types of studies or subgroup analyses based on higher absolute BC risk: BC family history (Type 1); early onset BC (Type 2); and/or genetic susceptibility (Type 3).

Methods

We systematically searched the PubMed database to identify epidemiologic studies examining ECE and BC risk published through June 1, 2019.

Results

We identified

SUBMITTER: Zeinomar N 

PROVIDER: S-EPMC7314105 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature