Impact of Fiber-Based Enteral Nutrition on the Gut Microbiome of ICU Patients Receiving Broad-Spectrum Antibiotics: A Randomized Pilot Trial.

ABSTRACT:

Objectives

Dietary fiber increases the abundance of bacteria that metabolize fiber into short-chain fatty acids and confers resistance against gut colonization with multidrug-resistant bacteria. This pilot trial estimated the effect of fiber on gut short-chain fatty acid-producing bacteria in the ICU.

Design

Randomized, controlled, open label trial.

Setting

Medical ICU.

Patients

Twenty ICU adults receiving broad-spectrum IV antibiotics for sepsis.

Intervention

1:1 randomization to enteral nutrition with mixed soy- and oat-derived fiber (14.3 g fiber/L) versus calorie- and micronutrient-identical enteral nutrition with 0 g/L fiber.

Measurements

Rectal swabs and whole stools were collected at baseline and on study Days 3, 7, 14, and 30. The primary

SUBMITTER: Freedberg DE 

PROVIDER: S-EPMC7314333 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature