Intravenous vs oral acetaminophen in sinus surgery: A randomized clinical trial.

ABSTRACT:

Background

Multimodal perioperative analgesia including acetaminophen is recommended by current guidelines. The comparative efficacy of intravenous vs oral acetaminophen in sinus surgery is unknown. We aimed to determine whether intravenous or oral acetaminophen results in superior postoperative analgesia following sinus surgery.

Methods

This was a prospective randomized trial with blinded endpoint assessments conducted at a single large academic medical center. Subjects undergoing functional endoscopic sinus surgery were randomized to intravenous vs oral acetaminophen in addition to standard anesthetic and surgical care. The primary outcome was visual analogue scale pain score at 1 hour postoperatively.

Results

One hundred and ten adult patients were randomized; 9 we

SUBMITTER: Bhoja R 

PROVIDER: S-EPMC7314478 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature