Vaccine-mediated protection against Campylobacter-associated enteric disease.

ABSTRACT: Campylobacter coli and Campylobacter jejuni are responsible for 400 million to 500 million cases of enteric disease each year and represent the most common cause of bacterial gastroenteritis worldwide. Despite its global importance, Campylobacter vaccine development has been hampered by the lack of animal models that recapitulate human disease pathogenesis. Here, we describe a naturally occurring Campylobacter-associated diarrhea model in outdoor-housed rhesus macaques. Using this model, we developed novel next-generation H₂O₂-based Campylobacter vaccines that induced strong antibacterial antibodies to multiple Campylobacter proteins including flagellin and provided up to 83% protection against severe C. coli-associated

SUBMITTER: Quintel BK 

PROVIDER: S-EPMC7314533 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature