Self-Generated Whisker Movements Drive State-Dependent Sensory Input to Developing Barrel Cortex.

ABSTRACT: Cortical development is an activity-dependent process [1-3]. Regarding the role of activity in the developing somatosensory cortex, one persistent debate concerns the importance of sensory feedback from self-generated movements. Specifically, recent studies claim that cortical activity is generated intrinsically, independent of movement [3, 4]. However, other studies claim that behavioral state moderates the relationship between movement and cortical activity [5-7]. Thus, perhaps inattention to behavioral state leads to failures to detect movement-driven activity [8]. Here, we resolve this issue by associating local field activity (i.e., spindle bursts) and unit activity in the barrel cortex of 5-day-old rats with whisker movements during wake and myoclonic twitches of the whiskers during

SUBMITTER: Dooley JC 

PROVIDER: S-EPMC7314650 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature