Deoxycholic acid modulates the progression of gallbladder cancer through N⁶-methyladenosine-dependent microRNA maturation.

ABSTRACT: Bile acids (BAs), well-defined signaling molecules with diverse metabolic functions, play important roles in cellular processes associated with many cancers. As one of the most common BAs, deoxycholic acid (DCA) is originally synthesized in the liver, stored in the gallbladder, and processed in the gut. DCA plays crucial roles in various tumors; however, functions and molecular mechanisms of DCA in gallbladder cancer (GBC) still remain poorly characterized. Here, we analyzed human GBC samples and found that DCA was significantly downregulated in GBC, and reduced levels of DCA was associated with poor clinical outcome in patients with GBC. DCA treatment impeded tumor progression by halting cell proliferation. DCA decreased miR-92b-3p expression in an m⁶A-dependent posttranscripti

SUBMITTER: Lin R 

PROVIDER: S-EPMC7314665 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature