Performance comparison of modified ComBat for harmonization of radiomic features for multicenter studies.

ABSTRACT: Multicenter studies are needed to demonstrate the clinical potential value of radiomics as a prognostic tool. However, variability in scanner models, acquisition protocols and reconstruction settings are unavoidable and radiomic features are notoriously sensitive to these factors, which hinders pooling them in a statistical analysis. A statistical harmonization method called ComBat was developed to deal with the "batch effect" in gene expression microarray data and was used in radiomics studies to deal with the "center-effect". Our goal was to evaluate modifications in ComBat allowing for more flexibility in choosing a reference and improving robustness of the estimation. Two modified ComBat versions were evaluated: M-ComBat allows to transform all features distributions to a chosen refere

SUBMITTER: Da-Ano R 

PROVIDER: S-EPMC7314795 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature