Serum branched-chain amino acids are associated with leukocyte telomere length and frailty based on residents from Guangxi longevity county.

ABSTRACT: Branched-chain amino acids (BCAAs) and telomere length are biologically associated with healthy aging. However, the association between them and their interaction on frailty remain unclear in humans. Here, a cross-sectional study based on residents from Guangxi longevity county was conducted to investigate the association of serum BCAAs, peripheral leukocyte telomere length (LTL) and frailty. A total of 1,034 subjects aged 20 to 110 years were recruited in the study. The real-time qPCR method and a targeted metabolomics approach based on isotope dilution liquid chromatography tandem mass spectrometry (LC/MS/MS) method were used for measurement of LTL and BCAAs, respectively. A frailty score defined as the proportion of accumulated deficits based on 24 aging-related items was used assess th

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7314839 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature