The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication.

ABSTRACT: Gastric and colorectal cancers have a high incidence and mortality worldwide. The presence of cancer stem cells (CSCs) within the tumor mass has been indicated as the main reason for tumor relapse, metastasis and therapy resistance, leading to poor overall survival. Thus, the elimination of CSCs became a crucial goal for cancer treatment. The identification of these cells has been performed by using cell-surface markers, a reliable approach, however it lacks specificity and usually differs among tumor type and in some cases even within the same type. In theory, the ideal CSC markers are those that are required to maintain their stemness features. The knowledge that CSCs exhibit characteristics comparable to normal stem cells that could be associated with the expression of similar transcrip

SUBMITTER: Padua D 

PROVIDER: S-EPMC7314965 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature