Cytomegalovirus Coinfection Is Associated with Increased Vascular-Homing CD57⁺ CD4 T Cells in HIV Infection.

ABSTRACT: Cytotoxic CD4 T cells are linked to cardiovascular morbidities and accumulate in both HIV and CMV infections, both of which are associated with increased risk of cardiovascular disease (CVD). In this study, we identify CMV coinfection as a major driver of the cytotoxic phenotype, characterized by elevated CD57 expression and reduced CD28 expression, in circulating CD4 T cells from people living with HIV infection, and investigate potential mechanisms linking this cell population to CVD. We find that human CD57⁺ CD4 T cells express high levels of the costimulatory receptor CD2 and that CD2/LFA-3 costimulation results in a more robust and polyfunctional effector response to TCR signals, compared with CD28-mediated costimulation. CD57⁺ CD4 T cells also express the vascul

SUBMITTER: Chen B 

PROVIDER: S-EPMC7315224 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature