Ancestry effects on type 2 diabetes genetic risk inference in Hispanic/Latino populations.

ABSTRACT:

Background

Hispanic/Latino (HL) populations bear a disproportionately high burden of type 2 diabetes (T2D). The ability to predict T2D genetic risk using polygenic risk scores (PRS) offers great promise for improved screening and prevention. However, there are a number of complications related to the accurate inference of genetic risk across HL populations with distinct ancestry profiles. We investigated how ancestry affects the inference of T2D genetic risk using PRS in diverse HL populations from Colombia and the United States (US). In Colombia, we compared T2D genetic risk for the Mestizo population of Antioquia to the Afro-Colombian population of Chocó, and in the US, we compared European-American versus Mexican-American populations.

Methods

Whole genome sequences and ge

SUBMITTER: Chande AT 

PROVIDER: S-EPMC7315475 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature