Synthesis and Evaluation of Novel Anticancer Compounds Derived from the Natural Product Brevilin A.

ABSTRACT: Cancer is the second leading cause of death globally, responsible for an estimated 9.6 million deaths in 2018, and this burden continues to increase. Therefore, there is a clear and urgent need for novel drugs with increased efficacy for the treatment of different cancers. Previous research has demonstrated that brevilin A (BA) exerts anticancer activity in various cancers, including human multiple myeloma, breast cancer, lung cancer, and colon carcinoma, suggesting the anticancer potential present in the chemical scaffold of BA. Here, we designed and synthesized a small library of 12 novel BA derivatives and evaluated the biological anticancer effects of the compounds in various cancer cell lines. The results of this structure-activity relationship study demonstrated that BA

SUBMITTER: Lee MM 

PROVIDER: S-EPMC7315608 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature