Optimisation of pyruvate hyperpolarisation using SABRE by tuning the active magnetisation transfer catalyst.

ABSTRACT: Hyperpolarisation techniques such as signal amplification by reversible exchange (SABRE) can deliver NMR signals several orders of magnitude larger than those derived under Boltzmann conditions. SABRE is able to catalytically transfer latent magnetisation from para-hydrogen to a substrate in reversible exchange via temporary associations with an iridium complex. SABRE has recently been applied to the hyperpolarisation of pyruvate, a substrate often used in many in vivo MRI studies. In this work, we seek to optimise the pyruvate-¹³C₂ signal gains delivered through SABRE by fine tuning the properties of the active polarisation transfer catalyst. We present a detailed study of the effects of varying the carbene and sulfoxide ligands on the formation

SUBMITTER: Tickner BJ 

PROVIDER: S-EPMC7315823 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature