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Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.

ABSTRACT: Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2 has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological agent of "coronavirus disease 2019", abbreviated to COVID-19, which despite only being identified at the very end of 2019, has now been classified as a pandemic by the World Health Organization (WHO). At this time, no specific prophylactic or postexposure therapy for COVID-19 are currently available. Viral entry is the first step in the SARS-CoV-2 lifecycle and is mediated by the trimeric spike protein. Being the first stage in infection, entry of SARS-CoV-2 into host cells is an extremely attractive therapeutic intervention point. Within this review, we highlight therapeutic intervention strategies for anti-SARS-CoV, MERS-CoV, and other coronaviruses and speculate upon future directions for SARS-CoV-2 entry inhibitor designs.

SUBMITTER: Xiu S

PROVIDER: S-EPMC7315836 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.

Xiu Siyu S Dick Alexej A Ju Han H Mirzaie Sako S Abdi Fatemeh F Cocklin Simon S Zhan Peng P Liu Xinyong X

Journal of medicinal chemistry 20200625 21

Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2 has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological agent of "coronavirus disease 2019", abbreviated to COVID-19, which despite only being identified at the very end of 2019, has now been classified as a pandemic by the World Health Organization (WHO). At this time, no specific prophylactic or postexposure therapy for COVID-19 are currently available. Viral entry is the f ...[more]

PMID: 32539378

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