Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes.

ABSTRACT: Obesity is the major contributing factor for the increased prevalence of type 2 diabetes (T2D) in recent years. Sustained positive influx of lipids is considered to be a precipitating factor for beta cell dysfunction and serves as a connection between obesity and T2D. Importantly, fatty acids (FA), a key building block of lipids, are a double-edged sword for beta cells. FA acutely increase glucose-stimulated insulin secretion through cell-surface receptor and intracellular pathways. However, chronic exposure to FA, combined with elevated glucose, impair the viability and function of beta cells in vitro and in animal models of obesity (glucolipotoxicity), providing an experimental basis for the propensity of beta cell demise under obesity in humans. To better understand the two-sided relati

SUBMITTER: Imai Y 

PROVIDER: S-EPMC7315845 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature