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Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment.

ABSTRACT: While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lungs. With its synthetic simplicity and in vivo efficacy in the veterinary setting, we contend that GS-441524 is superior to remdesivir for Covid-19 treatment.

SUBMITTER: Yan VC

PROVIDER: S-EPMC7315846 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment.

Yan Victoria C VC Muller Florian L FL

ACS medicinal chemistry letters 20200623 7

While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lungs. With its synthetic simplicity and in vivo efficacy in the veterinary setting, we contend that GS-441524 is superior to remdesivir for Covid-19 treatment. ...[more]

PMID: 32665809

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