Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk.

ABSTRACT:

Background

There is limited research on the interaction of both positive and negative daily-life environments with stress-related genetic variants on psychotic experiences (PEs) and negative affect (NA) across the extended psychosis phenotype. This study examined whether the FK506 binding protein 51 (FKBP5) variability moderates the association of positive and negative experiences in the moment with PEs and NA in participants with incipient psychosis and their nonclinical counterparts.

Methods

A total of 233 nonclinical and 86 incipient psychosis participants were prompted for a 1-week period to assess their day-to-day experiences. Participants were genotyped for four FKBP5 single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, and rs9470080).

Results

Multi

SUBMITTER: Cristobal-Narvaez P 

PROVIDER: S-EPMC7315877 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature