Frequency and Predictors of HIV-Related Cognitive Impairment in East Africa: The Africa Cohort Study (AFRICOS).

ABSTRACT:

Background

Medication adherence is a critical issue in achieving viral suppression targets, particularly in resource-limited countries. As HIV-related cognitive impairment (CI) impacts adherence, we examined frequency and predictors of CI in the African Cohort Study.

Setting

Cross-sectional examination of enrollment data from President's Emergency Plan for AIDS Relief supported clinic sites.

Methods

In a 30-minute cognitive assessment, CI was defined as -1SD on 2 tests or -2SD on one, as compared with 429 controls. We performed univariable and multivariable logistic and linear models examining clinical and demographic factors associated with CI and global neuropsychological performance (NP-6).

Results

Two thousand four hundred seventy-two HIV+ participants from

SUBMITTER: Milanini B 

PROVIDER: S-EPMC7316185 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature