Thyroid Function Affects the Risk of Stroke via Atrial Fibrillation: A Mendelian Randomization Study.

ABSTRACT: Observational studies suggest that variations in normal range thyroid function are associated with cardiovascular diseases. However, it remains to be determined whether these associations are causal or not. To test whether genetically determined variation in normal range thyroid function is causally associated with the risk of stroke and coronary artery disease (CAD) and investigate via which pathways these relations may be mediated. Mendelian randomization analyses for stroke and CAD using genetic instruments associated with normal range thyrotropin (TSH) and free thyroxine levels or Hashimoto's thyroiditis and Graves' disease. The potential mediating role of known stroke and CAD risk factors was examined. Publicly available summary statistics data were used. Stroke or CAD risk per geneti

SUBMITTER: Marouli E 

PROVIDER: S-EPMC7316221 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature