Implications of localized charge for human influenza A H1N1 hemagglutinin evolution: Insights from deep mutational scans.

ABSTRACT: Seasonal influenza A viruses of humans evolve rapidly due to strong selection pressures from host immune responses, principally on the hemagglutinin (HA) viral surface protein. Based on mouse transmission experiments, a proposed mechanism for immune evasion consists of increased avidity to host cellular receptors, mediated by electrostatic charge interactions with negatively charged cell surfaces. In support of this, the HA charge of the globally circulating H3N2 has increased over time since its pandemic. However, the same trend was not seen in H1N1 HA sequences. This is counter-intuitive, since immune escape due to increased avidity (due itself to an increase in charge) was determined experimentally. Here, we explore whether patterns of local charge of H1N1 HA can explain this discrepanc

SUBMITTER: Saad-Roy CM 

PROVIDER: S-EPMC7316228 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature