Detection of Human papillomavirus and the role of p16INK4a in colorectal carcinomas.

ABSTRACT:

Introduction

Human papillomavirus (HPV) infection is associated with the development of anogenital and head and neck cancers. In recent years a potential role of HPV in colorectal cancer (CRC) has been suggested.

Objective

To investigate the presence of HPV in colorectal carcinomas and to study the role of p16INK4a as a marker of transcriptionally active HPV infection. In addition, to investigate the correlation between these findings and the CRC prognostic factors.

Methods

Case control study with 92 cases of colorectal cancers, 75 controls of normal tissue adjacent to the tumor, and 30 controls of precursor lesions, including polyps and colorectal adenomas. Paraffinized samples were used, HPV detection and genotyping were performed by PCR and reverse hybridization by

SUBMITTER: Dalla Libera LS 

PROVIDER: S-EPMC7316293 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature