Associations between schistosomiasis and HIV-1 acquisition risk in four prospective cohorts: a nested case-control analysis.

ABSTRACT:

Introduction

Globally, schistosomes infect approximately 200 million people, with 90% of infections in sub-Saharan Africa. Schistosomiasis is hypothesized to increase HIV-1 acquisition risk, and multiple cross-sectional studies reported strong associations. We evaluated this hypothesis within four large prospective cohorts.

Methods

We conducted nested case-control analyses within three longitudinal cohorts of heterosexual HIV-1 serodiscordant couples and one female sex worker (FSW) cohort from Kenya and Uganda. The serodiscordant couples studies were conducted between 2004 and 2012 while the FSW cohort analysis included participant follow-up from 1993 to 2014. Cases HIV-1 seroconverted during prospective follow-up; three controls were selected per case. The presence of circu

SUBMITTER: Bochner AF 

PROVIDER: S-EPMC7316390 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature