Candida auris Phenotypic Heterogeneity Determines Pathogenicity In Vitro.

ABSTRACT: Candida auris is an enigmatic yeast that provides substantial global risk in health care facilities and intensive care units. A unique phenotype exhibited by certain isolates of C. auris is their ability to form small clusters of cells known as aggregates, which have been to a limited extent described in the context of pathogenic traits. In this study, we screened several nonaggregative and aggregative C. auris isolates for biofilm formation, where we observed a level of heterogeneity among the different phenotypes. Next, we utilized an RNA sequencing approach to investigate the transcriptional responses during biofilm formation of a nonaggregative and aggregative isolate of the initial pool. Observations from these analyses indicate unique transcriptional profiles in

SUBMITTER: Brown JL 

PROVIDER: S-EPMC7316489 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature