Girls' brain structural connectivity in late adolescence relates to history of depression symptoms.

ABSTRACT:

Background

Girls' depressive symptoms typically increase in adolescence, with individual differences in course and severity being key risk factors for impaired emotional functioning in young adulthood. Given the continued brain white matter (WM) maturation that occurs in adolescence, the present study tested whether structural connectivity patterns in late adolescence are associated with variation in the course of depression symptom severity throughout adolescence.

Method

Participants were girls (N = 115) enrolled in a multiyear prospective cohort study of risk for depression. Initial depression severity (intercept) at age 10 and change in severity (linear slope) across ages 10-19 were examined in relation to WM tractography collected at age 19. Network-based statistic analy

SUBMITTER: Chahal R 

PROVIDER: S-EPMC7316589 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature