Prospective study of the effects of sport-related concussion on serum kynurenine pathway metabolites.

ABSTRACT: Reports of neurodegenerative and psychiatric disease in former athletes have increased public concern about the acute and chronic effects of sport-related concussions (SRC). The biological factors underlying individual differences in the psychiatric sequalae of SRC and their role in potential long-term negative outcomes have not been determined. One understudied biological consequence of the known inflammatory response to concussion is the activation of a key immunoregulatory pathway, the kynurenine pathway (KP). Activation of the KP produces several neuroactive metabolites that have been associated with psychiatric and neurodegenerative diseases. We tested the hypothesis that SRC results in an elevation of serum KP metabolites with neurotoxic properties (quinolinic acid [QuinA], 3-hydroxy

SUBMITTER: Meier TB 

PROVIDER: S-EPMC7316609 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature