T-cell defects and postpartum depression.

ABSTRACT:

Background

Most studies of immune dysregulation in perinatal mood and anxiety disorders have focused on peripheral cytokines, but literature from non-perinatal mood disorders also implicates T-cell defects. We sought to characterize proportions of T-cell subtypes in women with postpartum depression.

Materials and methods

We enrolled 21 women with postpartum depression (PPD), 39 healthy postpartum controls, and 114 healthy non-postpartum women. Blood was collected in sodium-heparin EDTA tubes and was analyzed using flow cytometry. We conducted statistical tests including linear regression analysis that were aimed at determining differences in proportions of T cell populations among groups.

Results

Mean counts of T-cells (all CD3+ T cells), T-helper cells, (CD3+CD4+ T c

SUBMITTER: Osborne LM 

PROVIDER: S-EPMC7316619 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature