Deficiency of Nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and 2 reduces atherosclerosis.

ABSTRACT: Atherosclerosis is crucially fueled by inflammatory pathways including pattern recognition receptor (PRR)-related signaling of the innate immune system. Currently, the impact of the cytoplasmic PRRs nucleotide-binding oligomerization domain-containing protein (NOD) 1 and 2 is incompletely characterized. We, therefore, generated Nod1/Nod2 double knockout mice on a low-density lipoprotein receptor (Ldlr)-deficient background (= Ldlr^-/-Nod1/2^-/-) which were subsequently analyzed regarding experimental atherosclerosis, lipid metabolism, insulin resistance and gut microbiota composition. Compared to Ldlr^-/- mice, Ldlr^-/-Nod1/2^-/- mice showed reduced plasma lipids and increased hepatic expression of the scavenger receptor LDL receptor-relate

SUBMITTER: Vlacil AK 

PROVIDER: S-EPMC7316681 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature