Glycosyltransferase GT1 family: Phylogenetic distribution, substrates coverage, and representative structural features.

ABSTRACT: Glycosyltransferases (GTs) are responsible for transferring glycosyl moieties from activated sugar donors to certain acceptors, among which the GT1 family enzymes have been known for their outstanding glycosylation capacities toward diverse natural products, such as glycolipids, flavonoids and macrolides etc. However, there still lacks a systematic collation of this important family members. In this minireview, all the GT1 family sequences were phylogenetically analyzed, and the grouping of GT1 proteins exhibited a taxonomic life domain-dependent pattern, revealing many untapped clades of GTs. The further phylogenetic analysis of the characterized GTs facilitated the classification of substrates coverage of GT1 family enzymes from different life domains, whereby the GTs from bacteri

SUBMITTER: Zhang P 

PROVIDER: S-EPMC7316871 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature