Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects.

ABSTRACT: The neurulation process is regulated by a large amount of genetic and environmental factors that determine the establishment, folding, and fusion of the neural plate to form the neural tube, which develops into the main structure of the central nervous system. A recently described factor involved in this process is glutamate. Through NMDA ionotropic receptor, glutamate modifies intracellular Ca2+ dynamics allowing the oriented cell migration and proliferation, essentials processes in neurulation. Glutamate synthesis depends on the mitochondrial enzyme known as glutaminase 1 (GLS1) that is widely expressed in brain and kidney. The participation of GLS 1 in prenatal neurogenic processes and in the adult brain has been experimentally established, however, its participation in early stages of

SUBMITTER: Benavides-Rivas C 

PROVIDER: S-EPMC7316894 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature