Drosophila Exhibit Divergent Sex-Based Responses in Transcription and Motor Function After Traumatic Brain Injury.

ABSTRACT: Every year, millions of people in the US suffer brain damage from mild to severe traumatic brain injuries (TBI) that result from a sudden impact to the head. Despite TBI being a leading cause of death and disability worldwide, sex differences that contribute to varied outcomes post-injury are not extensively studied and therefore, poorly understood. In this study, we aimed to explore biological sex as a variable influencing response to TBI using Drosophila melanogaster as a model, since flies have been shown to exhibit symptoms commonly seen in other mammalian models of TBI. After inflicting TBI using the high-impact trauma device, we isolated w ¹¹¹⁸ fly brains and assessed gene transcription changes in male and female flies at control and 1, 2, and 4 hr after TBI.

SUBMITTER: Shah EJ 

PROVIDER: S-EPMC7316956 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature