Genome-Wide Identification of a Regulatory Mutation in BMP15 Controlling Prolificacy in Sheep.

ABSTRACT: The search for the genetic determinism of prolificacy variability in sheep has evidenced several major mutations in genes playing a crucial role in the control of ovulation rate. In the Noire du Velay (NV) sheep population, a recent genetic study has evidenced the segregation of such a mutation named FecL ^L . However, based on litter size (LS) records of FecL ^L non-carrier ewes, the segregation of a second prolificacy major mutation was suspected in this population. In order to identify this mutation, we have combined a case/control genome-wide association study with ovine 50k SNP chip genotyping, whole genome sequencing, and functional analyses. A new single nucleotide polymorphism (OARX:50977717T > A, NC_019484) located on the X chromosom

SUBMITTER: Chantepie L 

PROVIDER: S-EPMC7317000 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature