Pharmacokinetics of First-Line Drugs Among Children With Tuberculosis in Rural Tanzania.

ABSTRACT:

Background

Dosing recommendations for treating childhood tuberculosis (TB) were revised by the World Health Organization, yet so far, pharmacokinetic studies that have evaluated these changes are relatively limited. We evaluated plasma drug concentrations of rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA), and ethambutol (EMB) among children undergoing TB treatment in Tanzania when these dosing recommendations were being implemented.

Methods

At the end of intensive-phase TB therapy, blood was obtained 2 hours after witnessed medication administration to estimate the peak drug concentration (C2h), measured using high-performance liquid chromatography or liquid chromatography-tandem mass spectrometry methods. Differences in median drug concentrations were compared on the

SUBMITTER: Justine M 

PROVIDER: S-EPMC7317157 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature