Hypertension, Antihypertensive Use and the Delayed-Onset of Huntington's Disease.

ABSTRACT:

Background

Hypertension is a modifiable cardiovascular risk factor implicated in neurodegeneration and dementia risk. In Huntington's disease, a monogenic neurodegenerative disease, autonomic and vascular abnormalities have been reported. This study's objective was to examine the relationship between hypertension and disease severity and progression in Huntington's disease.

Methods

Using longitudinal data from the largest worldwide observational study of Huntington's disease (n = 14,534), we assessed the relationship between hypertension, disease severity, and rate of clinical progression in Huntington's disease mutation carriers. Propensity score matching was used to statistically match normotensive and hypertensive participants for age, sex, body mass index, ethnicity, and

SUBMITTER: Steventon JJ 

PROVIDER: S-EPMC7317197 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature