Molecular analysis of Chinese oesophageal squamous cell carcinoma identifies novel subtypes associated with distinct clinical outcomes.

ABSTRACT:

Background

Oesophageal squamous cell carcinoma (ESCC) is a highly heterogeneous cancer with a distinct incidence and prognosis. Molecular events driving ESCC subtypes and prognosis have not been established, and little is known regarding Chinese ESCC patients in Xinjiang, China.

Methods

Here, we first integrated the genomic and transcriptomic data of 125 Chinese ESCC patients from Xinjiang Tumor Hospital (Urumqi, China). Two independent datasets of GSE53624 and The Cancer Genome Atlas (TCGA) ESCC were used to confirm the results of this study. DNA mutation and overall survival (OS) were analysed independently in the Chinese ESCC cohorts.

Findings

Genomic analyses revealed a consistent mutation signatures and discordance among mutated genes across the different ESCC co

SUBMITTER: Liu M 

PROVIDER: S-EPMC7317223 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature