Learning Representations to Predict Intermolecular Interactions on Large-Scale Heterogeneous Molecular Association Network.

ABSTRACT: Molecular components that are functionally interdependent in human cells constitute molecular association networks. Disease can be caused by disturbance of multiple molecular interactions. New biomolecular regulatory mechanisms can be revealed by discovering new biomolecular interactions. To this end, a heterogeneous molecular association network is formed by systematically integrating comprehensive associations between miRNAs, lncRNAs, circRNAs, mRNAs, proteins, drugs, microbes, and complex diseases. We propose a machine learning method for predicting intermolecular interactions, named MMI-Pred. More specifically, a network embedding model is developed to fully exploit the network behavior of biomolecules, and attribute features are also calculated. Then, these discriminative features are

SUBMITTER: Yi HC 

PROVIDER: S-EPMC7317230 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature