Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure.

ABSTRACT:

Background

Despite intense research, it remains intriguing why hormonal therapies in general and progestins in particular sometimes fail in endometriosis.

Objective and rationale

We review here the action mechanisms of progesterone receptor ligands in endometriosis, identify critical differences between the effects of progestins on normal endometrium and endometriosis and envisage pathways to escape drug resistance and improve the therapeutic response of endometriotic lesions to such treatments.

Search methods

We performed a systematic Pubmed search covering articles published since 1958 about the use of progestins, estro-progestins and selective progesterone receptor modulators, to treat endometriosis and its related symptoms. Two reviewers screened the titles and ab

SUBMITTER: Reis FM 

PROVIDER: S-EPMC7317284 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature