Maternal and paternal effects on offspring internalizing problems: Results from genetic and family-based analyses.

ABSTRACT: It is unclear to what extent parental influences on the development of internalizing problems in offspring are explained by indirect genetic effects, reflected in the environment provided by the parent, in addition to the genes transmitted from parent to child. In this study, these effects were investigated using two innovative methods in a large birth cohort. Using maternal-effects genome complex trait analysis (M-GCTA), the effects of offspring genotype, maternal or paternal genotypes, and their covariance on offspring internalizing problems were estimated in 3,801 mother-father-child genotyped trios. Next, estimated genetic correlations within pedigree data, including 10,688 children, were used to estimate additive genetic effects, maternal and paternal genetic effects, and a shared fam

SUBMITTER: Jami ES 

PROVIDER: S-EPMC7317352 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature