HLA-EMMA: A user-friendly tool to analyse HLA class I and class II compatibility on the amino acid level.

ABSTRACT: In renal transplantation, polymorphic amino acids on mismatched donor HLA molecules can lead to the induction of de novo donor-specific antibodies (DSA), which are associated with inferior graft survival. To ultimately prevent de novo DSA formation without unnecessarily precluding transplants it is essential to define which polymorphic amino acid mismatches can actually induce an antibody response. To facilitate this, we developed a user-friendly software program that establishes HLA class I and class II compatibility between donor and recipient on the amino acid level. HLA epitope mismatch algorithm (HLA-EMMA) is a software program that compares simultaneously the HLA class I and class II amino acid sequences of the donor with the HLA amino acid sequences of the recipient and determines t

SUBMITTER: Kramer CSM 

PROVIDER: S-EPMC7317360 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature