Development and thyroid hormone dependence of skeletal muscle mitochondrial function towards birth.

ABSTRACT:

Key points

Skeletal muscle energy requirements increase at birth but little is known regarding the development of mitochondria that provide most of the cellular energy as ATP. Thyroid hormones are known regulators of adult metabolism and are important in driving several aspects of fetal development, including muscle fibre differentiation. Mitochondrial density and the abundance of mitochondrial membrane proteins in skeletal muscle increased during late gestation. However, mitochondrial functional capacity, measured as oxygen consumption rate, increased primarily after birth. Fetal hypothyroidism resulted in significant reductions in mitochondrial function and density in skeletal muscle before birth. Mitochondrial function matures towards birth and is dependent on the presence of th

SUBMITTER: Davies KL 

PROVIDER: S-EPMC7317365 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature