The clinical and prognostic significance of FOXN3 downregulation in acute myeloid leukaemia.

ABSTRACT:

Introduction

The expression of forkhead box N3 (FOXN3), also known as checkpoint suppressor 1 (CHES1), is reduced in many types of tumours. However, the clinical significance of FOXN3 and its potential role in acute myeloid leukaemia (AML) remain largely unknown.

Methods

A total of 117 de novo AML patients newly diagnosed between December 2015 and January 2018 were included in this study. The expression of FOXN3 and its clinical significance were analysed in these AML patients.

Results

The expression of FOXN3 was significantly downregulated in AML. In addition, lower FOXN3 expression was associated with older age and higher white blood cell counts. Moreover, a close correlation was observed between lower FOXN3 expression and a lower complete remission (CR) rate and sh

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7317382 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature