Genetic meta-analysis of obsessive-compulsive disorder and self-report compulsive symptoms.

ABSTRACT: We investigated whether obsessive-compulsive (OC) symptoms from a population-based sample could be analyzed to detect genetic variants influencing obsessive-compulsive disorder (OCD). We performed a genome-wide association studies (GWAS) on the obsession (rumination and impulsions) and compulsion (checking, washing, and ordering/precision) subscales of an abbreviated version of the Padua Inventory (N = 8,267 with genome-wide genotyping and phenotyping). The compulsion subscale showed a substantial and significant positive genetic correlation with an OCD case-control GWAS (r _G = 0.61, p = .017) previously published by the Psychiatric Genomics Consortium (PGC-OCD). The obsession subscale and the total Padua score showed no significant genetic correlations (r _G = -0.02 a

SUBMITTER: Smit DJA 

PROVIDER: S-EPMC7317414 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature