Doxorubicin-induced skeletal muscle atrophy: Elucidating the underlying molecular pathways.

ABSTRACT:

Aim

Loss of skeletal muscle mass is a common clinical finding in cancer patients. The purpose of this meta-analysis and systematic review was to quantify the effect of doxorubicin on skeletal muscle and report on the proposed molecular pathways possibly leading to doxorubicin-induced muscle atrophy in both human and animal models.

Methods

A systematic search of the literature was conducted in PubMed, EMBASE, Web of Science and CENTRAL databases. The internal validity of included studies was assessed using SYRCLE's risk of bias tool.

Results

Twenty eligible articles were identified. No human studies were identified as being eligible for inclusion. Doxorubicin significantly reduced skeletal muscle weight (ie EDL, TA, gastrocnemius and soleus) by 14% (95% CI: 9.9; 19.3)

SUBMITTER: Hiensch AE 

PROVIDER: S-EPMC7317437 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature