Psoriasis treat to target: defining outcomes in psoriasis using data from a real-world, population-based cohort study (the British Association of Dermatologists Biologics and Immunomodulators Register, BADBIR).

ABSTRACT:

Background

The 'treat to target' paradigm improves outcomes and reduces costs in chronic disease management but is not yet established in psoriasis.

Objectives

To identify treatment targets in psoriasis using two common measures of disease activity: Psoriasis Area and Severity Index (PASI) and Physician's Global Assessment (PGA).

Methods

Data from a multicentre longitudinal U.K. cohort of patients with psoriasis receiving systemic or biologic therapies (British Association of Dermatologists Biologics and Immunomodulators Register, BADBIR) were used to identify absolute PASI thresholds for 90% (PASI 90) and 75% (PASI 75) improvements in baseline disease activity, using receiver operating characteristic curves. The relationship between PGA (clear, almost clear, mild, mo

SUBMITTER: Mahil SK 

PROVIDER: S-EPMC7317460 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature