The organizing principle of GABA_B receptor complexes: Physiological and pharmacological implications.

ABSTRACT: GABA_B receptors (GBRs), the G protein-coupled receptors for the neurotransmitter γ-aminobutyric acid (GABA), regulate synaptic transmission at most synapses in the brain. Proteomic approaches revealed that native GBR complexes assemble from an inventory of ~30 proteins that provide a molecular basis for the functional diversity observed with these receptors. Studies with reconstituted GBR complexes in heterologous cells and complementary knockout studies have allowed to identify cellular and physiological functions for obligate and several non-obligate receptor components. It emerges that modular association of receptor components in space and time generates a variety of multiprotein receptor complexes with different localizations, kinetic properties and effector channels. This

SUBMITTER: Fritzius T 

PROVIDER: S-EPMC7317483 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature